After 2023 excellent preclinical results in NAFLD/NASH in vivo murine models, Endolipid starts the regulatory development of the SHBG-mimic peptide EDL6D to move the new treatment option closer to patients in need
Senior Executive and Development Consultant / Former CEO ABAC Therapeutics and Head of Med Chemistry at Ferrer and Menarini / Boards member and advisor to start-ups in Spain, Belgium, and S Africa / Co-developer of the NSAID analgesic Enantyum® and the quinolone antibiotic Ozanex®.
David M. Selva,
Board Member and Scientific Leader / Worldwide expert and KOL on SHBG / Extensive experience on molecular mechanisms regulating SHBG and its role in human disease development / More than 30 papers published in top international journals.
Rafael Simó, MD, Prof
Head of Endocrinology and Nutrition Department / Deputy Director of Clinical Research at Campus Vall d’Hebron / Professor of Medicine & Endocrinology. Universitat Autònoma de Barcelona / President of the European Association for the Study of Diabetes- Eye Complications.
Financial officer in several start-up companies Cority, Aortix, Endolipid, etc Finance and tax consultant at the FI-Ready Group of Companies.
Anna Alvarez, PhD
In vivo models
Laura Brianso, PhD
In vitro models
Who are we?
What we do?
How we do it?
Pathologies Derived from Fat Accumulation
Increased ectopic fat accumulation:
Fatty liver and NASH
- Liver fat accumulation, fibrosis and inflammation leading to cirrhosis.
- Silent disease, low awareness and poor diagnosis.
- Co-morbidities obesity, diabetes, hyperlipidemia and hypertension.
- Undesirable fat deposits in subcutaneous adipocyte.
- Socially subterfuge disease affecting +80% pot-puberal females.
- Scarce science-based innovation in the last decade.
Endolipid proposed strategy:
Sex Hormone Binding Globulin (SHBG)
Mimicking SHBG, an innovative new strategy to reduce ectopic fat accumulation.
Sex Hormone-Binding Globulin
- Plasma glycoprotein
- Produced by the liver and secreted Into the blood.
- Binds sex steroids.
- Low plasma SHBG levels related to subjects with obesity, fatty liver, type 2 diabetes and PCOS.
(1) Lipolysis: Sáez-López et al 2020 J Nutr Biochem.
(2) Lipogenesis: Sáez-López et al 2015 and 2017 Endocrinology.
(3) Lipogenesis, Inflammation: Sáez-López et al 2019 JCEM),
(4) Fibrosis: Selva DM et al unpublished.
(5) Inflammation: Yamazaki H et al 2018 Mediators Inflamm.
The ENDOLIPID Technology.
Peptides mimicking SHBG are useful to treat fatty liver diseases and reduce cellulite.
Therapeutic and dermocosmetic applications.
Co-development and license to